| Pair Name | Beta-Sitosterol, Gemcitabine | ||
| Phytochemical Name | Beta-Sitosterol (PubChem CID: 222284 ) | ||
| Anticancer drug Name | Gemcitabine (PubChem CID: 60750 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Beta-Sitosterol, Gemcitabine | |||
| Disease Info | [ICD-11: 2C10] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CDH1 | hsa999 | |
| Down-regulation | Phosphorylation | GSK3B | hsa2932 | |
| Down-regulation | Phosphorylation | NFKB1 | hsa4790 | |
| Down-regulation | Expression | SNAI1 | hsa6615 | |
| Down-regulation | Expression | VIM | hsa7431 | |
| In Vitro Model | MIA PaCa-2 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0428 |
| BxPC-3 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0186 | |
| In Vivo Model | BXPC-3 cells (0.2 mL; 7×10⁶ cells) were subcutaneously injected into the right flank of the nude mice. | |||
| Result | β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling | |||
| No. | Title | Href |
|---|---|---|
| 1 | β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-Pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling. Front Pharmacol. 2020 Nov 20;11:565535. doi: 10.3389/fphar.2020.565535. | Click |
